Lead and zinc influence on antioxidant enzyme activity and malondialdehyde concentrations
Kulikowska-Karpinska E, Moniuszko-Jakoniuk J
Kulikowska-Karpinska E, Med Univ, Dept Toxicol, Ul Mickiewicz 2, PL-15222 Bialystok, Poland
Med Univ, Dept Toxicol, PL-15222 Bialystok, Poland
Med Univ, Dept Toxicol, PL-15222 Bialystok, Poland
Pol. J. Environ. Stud. 2001;10(3):161–165
KEYWORDS
ABSTRACT
The influence of zinc on the activity of antioxidant enzymes in the blood of rats intoxicated with lead was studied. Exposure to lead at the concentration of 500 mg/dm(3) for 6 weeks caused a decrease in the activities of SOD, GSH-P-x and GR as well as an increase in MDA concentrations in the serum. Zinc at the concentration of 60 mg/dm(3) administered for a period of 2 weeks after exposure to cadmium reduced the effects of toxic action of lead leading to a normalization of the activities of SOD and GR in the blood as well as MDA concentration in the serum.
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