Lead and zinc influence on antioxidant enzyme activity and malondialdehyde concentrations
Kulikowska-Karpinska E, Moniuszko-Jakoniuk J
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Kulikowska-Karpinska E, Med Univ, Dept Toxicol, Ul Mickiewicz 2, PL-15222 Bialystok, Poland
Med Univ, Dept Toxicol, PL-15222 Bialystok, Poland
Pol. J. Environ. Stud. 2001;10(3):161-165
The influence of zinc on the activity of antioxidant enzymes in the blood of rats intoxicated with lead was studied. Exposure to lead at the concentration of 500 mg/dm(3) for 6 weeks caused a decrease in the activities of SOD, GSH-P-x and GR as well as an increase in MDA concentrations in the serum. Zinc at the concentration of 60 mg/dm(3) administered for a period of 2 weeks after exposure to cadmium reduced the effects of toxic action of lead leading to a normalization of the activities of SOD and GR in the blood as well as MDA concentration in the serum.
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