In order to explore the comprehensive assessment method of air quality of pollutant emission of energy consumption in China’s urban internal industrial parks, based on the full consideration of the actual situation of air pollution control in Nanjing HX Industry Park, this paper selects 15 air quality assessment indicators. According to the national air quality standard, the air quality standard of Nanjing and the air quality standard of Nanjing HX Industry Park, the air quality assessment standard is determined about pollutant emission of energy consumption in Nanjing HX Industry Park. Through the technical treatment of the selected assessment indicators, the niche suitability model is introduced, and based on this, the spatial niche suitability model is reconstructed to comprehensively assess the air quality of pollutant emission of energy consumption in Nanjing HX Industry Park. The study found that the air quality of Nanjing HX Industry Park has been improved from level III in 2012 to level I in 2020. According to the assessment results, the differences of assessment results of different niche suitability models are discussed, which fully reflects the advantages of spatial niche assessment methods. The change law and influencing factors of the assessment results are further discussed.