Bisphenol A (BPA), an important component of the plastics industry, is characterized as an endocrine disrupting toxic substance for aquatic organisms. This study focused on the toxic effects of BPA on endangered Danube sturgeon larvae (Acipenser gueldenstaedtii). In the study, LC₅₀ values for five different BPA concentrations (100, 200, 400, 800, 1200 μg/L) were observed as 803.4 μg/L, 63.1 μg/L, and 39.6 μg/L at 24^th, 48^th a nd 72^nd hours, respectively. Especially, the lethal effect of BPA on the larvae was remarkable after the 24^th hour. On the other hand, histopathological changes were examined based on the LC₅₀ value at the 24^th hour. Vacuolization symptom was noted in the gills of the larvae. In addition, vacuolization and melanomacrophage centers caused a severe degradation in liver and kidney tissues of BPA group. In the intestine, the number of goblet cells per ville was lower in the BPA group. As a result, it has been proven by LC₅₀ and histopathological studies that BPA has high toxicity in A. gueldenstaedtii larvae.