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eISSN: 2083-5906
ISSN: 1230-1485
ISSN: 1230-1485
SHORT COMMUNICATION
Cytotoxicity and Antimicrobial Activity of Pivalic
and Benzoic Acid-Complexed Cu
and Mn Complexes
Bashrat Ali1, Sadia Tahir1, M. Nadeem Akhtar1, Muhammad Yameen2, Rizwan Ashraf1, Tariq Hussain3, Abdul Ghaffar2, Mazhar Abbas3, Tanveer H. Bokhari5, Munawar Iqbal2
1Department of Chemistry, University of Agriculture, Faisalabad 38040, Pakistan
2Department of Applied Chemistry and Biochemistry, GC University, Faisalabad, Pakistan
3Jhang-Campus, University of Veterinary & Animal Sciences Lahore, Pakistan
4Department of Chemistry, The University of Lahore, Lahore, Pakistan
5Department of Chemistry, GC University, Faisalabad, Pakistan
2Department of Applied Chemistry and Biochemistry, GC University, Faisalabad, Pakistan
3Jhang-Campus, University of Veterinary & Animal Sciences Lahore, Pakistan
4Department of Chemistry, The University of Lahore, Lahore, Pakistan
5Department of Chemistry, GC University, Faisalabad, Pakistan
Submission date: 2016-10-06
Final revision date: 2017-01-13
Acceptance date: 2017-01-16
Online publication date: 2017-10-13
Publication date: 2017-11-07
Pol. J. Environ. Stud. 2017;26(6):2861-2867
KEYWORDS
TOPICS
ABSTRACT
The complexes of Cu and Mn metals with carboxylates (pivalic acid and benzoic acid) and imidazole were prepared and characterized. The synthesized complexes were screened for antimicrobial activity and cytotoxicity. The FTIR technique was used for characterization. The antibacterial assay revealed that the ligand and complexes are active against Escherichia coli, Staphylococcus aureus and Pasteurella multocida bacterial strains. The haemolytic assay revealed that [Cu(imi)(N3)] and [MnIII(piv)(imi)(N3)] were nontoxic, whereas [Cu(piv)(imi)] and [MnIII(Benz)(imi)(OCH3)] showed moderate toxicity, and [Mn(Him)(N3)2] was highly toxic against human red blood cells (RBCs). Results revealed that Cu and Mn complexes with carboxylates (pivalic acid and benzoic acid) have antimicrobial activities. However, haemlytic assay revealed that the metal complex cytotoxicity was variable and biological activity evaluatuion of newly synthesized metals complexes is suggested for safe applications.
CONFLICT OF INTEREST
The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
CITATIONS (5):
1.
Abundance and Sources of Phthalic Acids, Benzene-Tricarboxylic Acids, and Phenolic Acids in PM2.5 at Urban and Suburban Sites in Southern China
Xiao He, X. H. Hilda Huang, Ka Shing Chow, Qiongqiong Wang, Ting Zhang, Dui Wu, Jian Zhen Yu
ACS Earth and Space Chemistry
Xiao He, X. H. Hilda Huang, Ka Shing Chow, Qiongqiong Wang, Ting Zhang, Dui Wu, Jian Zhen Yu
ACS Earth and Space Chemistry
2.
A comparative investigation on the surface and physicochemical properties of organobimetallic thiocyanate complexes of Cadmium, Zinc, Mercury and Manganese
Sundararaj Cynthia, Sankar Muthupandi, Gopal Ramalingam, Subbarayan Sathiyamurthy, Yassine Slimani, Munirah A. Almessiere, Abdulhadi Baykal, Saravana Kumar Jaganathan, Markasagayam Visagamani Arularasu, Anish Khan, Manikandan Ayyar
Zeitschrift für Physikalische Chemie
Sundararaj Cynthia, Sankar Muthupandi, Gopal Ramalingam, Subbarayan Sathiyamurthy, Yassine Slimani, Munirah A. Almessiere, Abdulhadi Baykal, Saravana Kumar Jaganathan, Markasagayam Visagamani Arularasu, Anish Khan, Manikandan Ayyar
Zeitschrift für Physikalische Chemie
3.
Comprehensive Insights into Medicinal Research on Imidazole-Based Supramolecular Complexes
Shu-Rui Li, Yi-Min Tan, Ling Zhang, Cheng-He Zhou
Pharmaceutics
Shu-Rui Li, Yi-Min Tan, Ling Zhang, Cheng-He Zhou
Pharmaceutics
4.
Molecular structures of two copper complexes with the pharmaceuticals norfloxacin and tinidazole, when powder X-ray diffraction assists multi-domain single-crystal X-ray diffraction
Gloria Elena Tobón Zapata, Dina Marcela Martínez Carmona, Gustavo Alberto Echeverría, Oscar Enrique Piro
Acta Crystallographica Section B Structural Science, Crystal Engineering and Materials
Gloria Elena Tobón Zapata, Dina Marcela Martínez Carmona, Gustavo Alberto Echeverría, Oscar Enrique Piro
Acta Crystallographica Section B Structural Science, Crystal Engineering and Materials
5.
Characterization of benzene polycarboxylic acids and polar nitroaromatic compounds in atmospheric aerosols using UPLC-MS/MS
Mahmoud M. Yassine, Michal Suski, Ewa Dabek-Zlotorzynska
Journal of Chromatography A
Mahmoud M. Yassine, Michal Suski, Ewa Dabek-Zlotorzynska
Journal of Chromatography A
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| eISSN: | 2083-5906 |
| ISSN: | 1230-1485 |
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