A response surface optimization based on ionic liquid dispersive liquid phase microextraction was developed for analysis of the endocrine disrupting compounds bisphenol A and 4-nonylphenol in water samples. The volume of the extraction solvent, volume of dispersive solvent, and pH were found to have significant effects on the response. Analysis of variance indicated that the model was significant at a high level. The reproducibility was investigated in six replicate experiments under optimum conditions. Taken together, these results indicated that the developed method would be a useful green method for rapid determination of bisphenol A and 4-nonylphenol at trace levels in tap and surface waters.