The rapid development of Chengdu-Chongqing Economic Circle (CCEC) has caused damage to the ecological environment. Exploring changes in the ecological resilience of Chengdu-Chongqing Economic Circle and improving post-disaster resilience will help improve the green, healthy and sustainable development of similar urban agglomerations in Chengdu-Chongqing Economic Circle. Considering 16 cities in Chengdu-Chongqing Economic Circle as examples, this paper uses the entropy and the linear weighting methods to calculate the ecological resilience level of Chengdu-Chongqing Economic Circle. Using the obstacle degree model, the paper studies the influence factors of ecological resilience level. Finally, Moran's I is used to study the spatial autocorrelation of the ecological resilience of Chengdu-Chongqing Economic Circle. The results show: (1) The overall ecological resilience level of Chengdu-Chongqing Economic Circle is showing an upward trend, but it is currently at an intermediate stage. (2) Disasters have a greater impact on the level of ecological resilience. (3) The spatial autocorrelation of CCEC has changed from negative correlation to positive correlation and then to negative correlation.