This study aims to develop a comprehensive, objective, and effective method for testing and evaluating the overall pollutant purification capability of vehicles, especially on practicality and reliability. Three performance indicators: the pollutant barrier of vehicles under static conditions, the purification of particulate pollutants, and the purification capacity of toxic and harmful gases, are mainly evaluated. Seven pollution scenarios and driving conditions, including static parking, sandstorms, cooking fumes, automotive exhaust, indoor smoking, industrial emissions, and hightemperature exposure, are established and assimilated. These scenarios were utilized to assess the purification capabilities of vehicles for particulate matter and toxic gases. Based on our method, seven vehicle models (each with different in-car purification configurations) were selected for testing. The results demonstrate that the numerical values of comprehensive pollutant purification capacity are related to the configuration levels of in-car purification devices, showing clear numerical differentiation. These values indicate the ability of vehicles to continuously, effectively, and reliably purify pollutants under typical pollution scenarios. Therefore, this comprehensive purification capability evaluation method provides a robust framework for assessing the pollutant purification capabilities of vehicles equipped with complex in-car purification systems.