Evaluating ecological livability is to consider the balance between urban development and ecological sustainability from an ecological perspective. This study takes the ecological environment of seven counties in the Huizhou region as the object of study and summarizes an ecological livability index system of evaluation which includes 18 indexes across five criteria: human habitat, resource utilization, ecological maintenance, pollution treatment, and climatic environment. Using the entropy weight- TOPSIS method, the study evaluates and analyzes the factors influencing the ecological livability of each region. The spatio-temporal differentiation characteristics of the region are then analyzed using ArcMap 10.8 to provide an example for ecological environment maintenance in the Huizhou region. The following conclusions were obtained: (1) The overall level of urban eco-livability in Huangshan City, Huizhou region, is low, with a slow downward trend before 2019 and a rapid increase after 2019, with the highest district and county eco-livability scores reaching “general level”. (2) Huizhou’s ecological livability level is spatially structured around the urban region, with the structural features of “high in the central area and poor in the periphery” and a tendency to radiate and extend outward from the center. (3) By comparing the weighting coefficients of the evaluation indicators, it is found that the four indicators of daily per capita domestic water consumption (C9), green space and plaza land (C3), annual precipitation (C6), and current year afforestation area (C12) are the main factors influencing the ecological livability.