Focusing on the implementation of the Yellow River strategy in the lower reaches of the Yellow River to achieve high-quality development of economy and ecological environment, we analyzed the spatial and temporal variation characteristics of the industrial ecological level in the lower reaches of the Yellow River from 2007 to 2020 and the main obstacle factors by using coupled coordination analysis and obstacle model. The results show that the level of industrial ecology in the lower reaches of the Yellow River has been increasing year by year during the study period, showing a trend of “decreasing first, then increasing”, and a slow increase in general, but the quality coordination still needs to be continued; there are significant differences in the level of industrial ecology in the lower reaches of the Yellow River cities, and the spatial pattern distribution shows There are significant differences in the level of industrial ecology in the lower Yellow River cities, and the distribution of spatial pattern shows the characteristics of “high in the middle and low on both sides” and “gradually decreasing from east to west”; the main obstacle factors affecting the development of industrial ecology come from the industrial system, such as the number of effective patents granted, the proportion of foreign investment in GDP, and the regional GDP growth rate have The main obstacles to the development of industrial ecology come from the industrial system. In this regard, it is proposed to reduce the energy consumption and pollution level of enterprises and improve the ability of resource recycling at the micro level; to optimize the industrial structure and layout at the macro level, to strengthen scientific and technological innovation, to enhance the level of economic opening to the outside world, and to realize the coordinated development of industry and ecosystem.