Scientific and technological innovation and the sustainable development of new urbanization are the key factors to promote national economic growth, and have a very important role in promoting regional development and international competitiveness. Based on the panel data of 16 cities in Chengdu-Chongqing dual-city economic circle from 2015 to 2022, this paper uses entropy weight method to determine the weight of each index and constructs a coupling coordination model to explore the sustainable development of scientific and technological innovation and new urbanization, the Panel Vector Autoregression (PVAR) model was used to further verify the interaction between the two. The empirical results show that the coupling coordination degree of scientific and technological innovation and new urbanization in Chengdu-Chongqing economic circle is increasing year by year. There is a balanced relationship between scientific and technological innovation and new urbanization, and the two are two-way Granger causality. Therefore, the conclusion puts forward the practical enlightenment of increasing investment in scientific and technological innovation, guiding enterprises to carry out scientific and technological innovation to feedback new urbanization and accelerate the construction of new urbanization, and actively integrating with urban development.