This study presents the characterization and results of applying a mineral mixture to lettuce cultivation, aiming to enhance nutritional input throughout the entire growth cycle of the plant. The mixture consists of three components: feldspathic rock, commercial expanded perlite (PER), and phosphate rock (PR). For the experimental development, two types of feldspathic rock were used: one extracted from the state of Hidalgo, Mexico (RH), and another from Veracruz, Mexico (RV). Both were characterized and applied independently. The feldspathic rocks from Hidalgo and Veracruz were subjected to a cation exchange treatment by immersion in an ammonium solution. Subsequently, they were mixed in different proportions with non-exchanged feldspathic rock, expanded perlite, and phosphate rock, resulting in six different mineral mixtures. Each mineral used was characterized: the crystalline phases were identified using X-ray diffraction (XRD), elemental composition was analyzed by X-ray fluorescence (XRF), and crystal morphology was examined via scanning electron microscopy (SEM). Only the ammonium-exchanged feldspathic rocks were analyzed for the texture and the cation exchange capacity using ICP-OES. The effects of the six mineral mixtures on lettuce cultivation were evaluated by measuring root length, fresh weight, and dry matter content. Results show that lower nutrient availability leads to increased root growth and higher dry matter percentage. Thus, the use of mineral substrates is proposed as a costeffective and widely available alternative for lettuce crop nutrition.