The coupling coordination of digital economy and green high-quality development of industries is an important way for sustainable and high-quality economic development. This paper constructs an evaluation index system for the digital economy and industrial green high-quality development, and conducts empirical analysis using the coupling coordination model, the spatial autocorrelation model, and the Tobit model. The data from provinces and cities in the Yangtze River Economic Belt spanning from 2008 to 2021 has been analyzed. Results show that both subsystems exhibit a good and rising coupling coordination, and the regional coupling coordination demonstrates a trend of higher values in the east and lower in the west. Moreover, there is interaction between provinces and cities, albeit with a weakening correlation after 2011. Additionally, spatial clustering is evident between regions with high and low coupling coordination. The coupling coordination degree of each region is impacted by important factors, such as economic development level, financial level, opening up, fiscal expenditure, and urbanization. Therefore, the study recommends policies aimed at boosting the coupling coordination level in the Yangtze River Economic Belt. Key policy proposals contain promoting the integration and innovation of digital technology and green low-carbon technology, strengthening regional cooperation through the transfer of industries, and adopting differentiated development strategies tailored to regional advantages and the varied impact.