Toxicity of Diclofenac and its Biotransformation by Raoultella sp. DD4

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About the Journal In Memory of Professor Jerzy Radecki Ownership and Management Statement Editorial Office Editorial Board Scope Impact Factor Indexed by Journal Impact Factor contributing items Publication Frequency Revenue Sources & Business Model Contact Subscription

Current issue

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Instructions for Authors Copyright & Licensing Publication Fees

Editorial policies Publication Policy Overview Peer Review Policy Research Ethics and Malpractice Policy Plagiarism Policy Conflict of Interest Policy Open Access Policy Instructions for Reviewers Generative AI and AI-Assisted Technologies Policy Advertising Policy Direct Marketing & Manuscript Solicitation Digital Archiving and Preservation Policy CrossMark, Correction, and Retraction Policy

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SHORT COMMUNICATION

Toxicity of Diclofenac and its Biotransformation by Raoultella sp. DD4

Dorota Domaradzka, Urszula Guzik, Katarzyna Hupert-Kocurek, Danuta Wojcieszyńska

Department of Biochemistry, Faculty of Biology and Environmental Protection, University of Silesia in Katowice,
Jagiellońska 28, 40-032 Katowice, Poland

Submission date: 2016-03-08

Final revision date: 2016-04-12

Acceptance date: 2016-04-14

Publication date: 2016-10-05

Pol. J. Environ. Stud. 2016;25(5):2211-2216

DOI: https://doi.org/10.15244/pjoes/62681

KEYWORDS

biotransformation

TOPICS

ABSTRACT

In recent years the increased consumption of diclofenac, a biologically active compound that is toxic to organisms and persistent to biodegradation, has resulted in its presence in the environment. This is the first report on the biotransformation of diclofenac by a pure bacterial strain, Raoultella sp. DD4, which is able to transform 0.6 mg/L of diclofenac in 28 days. Additionally, strain DD4 is more resistant to diclofenac than other tested organisms. The estimated value for EC50 for this strain is 1.95 g/L. This is approximately five-fold higher than the value of microbial toxic concentration MTC_avg (0.416 g/L). Moreover, genotoxicity studies have indicated that diclofenac is not a mutagenic compound.

CONFLICT OF INTEREST

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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