From the perspective of supply and demand, in view of the unreasonable structure of logistics system and the inefficient use of logistics resources, a matching measurement method system of regional logistics system structure and logistics resources based on quantity, structure, space and time (QSST) equilibrium is proposed, mainly including the matching mechanism and process model, matching measurement model and matching discrimination analysis. It mainly includes the matching mechanism and process model, matching measurement model, and matching degree discriminant analysis. Combined with the coupled coordination degree model, an example analysis of the matching degree of logistics system structure and logistics resources in China is conducted using relevant panel data from 2011 to 2020, and the study confirms that structural mismatch is currently an important element affecting the sustainable development of China’s logistics industry. This theory and method can better evaluate the matching state of logistics structure and resources, find the individual advantages of the matching relationship between the two in different stages, make a correct analysis and evaluation of the evolution trend of the matching relationship between the two, and then provide a basis for managers to plan the green, healthy and sustainable logistics structure.