Recently, the increasing concentration of people in urban areas has raised concerns about the geochemistry of trace and toxic elements in urban soil. Surface soil plays an important role in human exposure through ingestion, dermal contact, and inhalation. However, studies on urban soils associated with trace and toxic elements are quite limited in South America. This work presents the first geochemical approach to urban soil in the city of Chillán, Chile. The levels of As, Cu, Sr, and Zn were measured in topsoil (0-10 cm depth) samples (n = 174) collected across a 500-m grid, chosen to be representative of the entire urban area within the city. The hazard index (HI) and carcinogenic risk (CR) were used to assess the human health risk of trace and toxic elements. The mean concentrations for Cu, Zn, As, and Sr were 71.8, 229.8, 11.2, and 234.6 μg/g dw, respectively. The values of HI for children and adults present a descending order of Cu > Sr > Zn > As. The CR values of As, Cu, Sr, and Zn were within an acceptable range for both age groups. This information will be useful to implement plans to prevent possible human exposure to toxic compounds in urban environments in future landscapes.