Covering 3168 annual observations of 132 countries for 1995-2018, the study investigated the role of knowledge spillover (KNOW), renewable energy (RE) demand, and food production (FP) in mitigation of CO₂ emissions to achieve global environmental sustainability (ES) agenda. The study used Arellano- Bond (A-R) differenced GMM estimator to handle endogeneity and serial correlation issues for robust inferences. The results confirmed the hump-shaped relationship between KNOW and CO₂ emissions to support ‘Knowledge Kuznets curve (KKC)’ across countries. The results further reveal that FDI inflows and trade openness (TOP) both increases CO₂ emissions that substantiate the ‘pollution haven hypothesis (PHH)’. The positive relationship between FP and CO₂ emissions exhibits ‘food footprints (FFP)’ across countries. The negative relationship between RE demand and CO₂ emissions imply that increased use of RE helps to reduce emissions, which is a positive sign to precede towards cleaner production technologies for achieving global ES agenda.